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FLASH GENE
Symbol GNL3L contributors: mct - updated : 04-11-2011
HGNC name guanine nucleotide binding protein-like 3 (nucleolar)-like
HGNC id 25553
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a circularly permuted G-motif described by a G5-G4-G1-G2-G3 pattern similar to the HSR1/MMR1 GTP-binding protein subfamily
  • lysine-rich nucleolar localization signal (NoLS) residing within 1-50 amino acid residues, for the transport in the nucleole (necessary and sufficient to target the heterologous proteins to the nucleolus)
    • HOMOLOGY
    interspecies homolog to murine Gnl3l (88.2pc)
    intraspecies paralog to nucleostemin
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • putative GTPase activity
  • is required for growth and plays a role in processing of nucleolar pre-rRNA
  • composed of distinct modules, each of which plays a specific role in molecular interactions for its nucleolar retention and subsequent function(s) within the nucleolus
  • is able to reduce the steroid receptor coactivator (SRC) binding and the SRC-mediated transcriptional coactivation of ESRRG
  • TERF1 protein-stabilizing activity of GNL3L mediates the mitotic increase of TERF1 protein and promotes the metaphase-to-anaphase transition
  • GNL3L and nucleostemin are the only two that are designed to stabilize MDM2 protein under basal or induced condition, respectively, and may act as tumor-promoting genes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • TERF1-interacting protein (binds TERF1 in the nucleoplasm and is capable of promoting the homodimerization and telomeric association of TERF1, preventing promyelocytic leukemia body recruitment of telomere-bound TERF1)
  • MDM2 regulator (GNL3L binds MDM2 and displays the same function as nucleostemin in stabilizing MDM2 protein and preventing its ubiquitylation)
  • TERF1 dimerization is actively and oppositely regulated by GNL3 and GNL3L extrachromosomally
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS