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FLASH GENE
Symbol GNL3L contributors: mct - updated : 04-11-2011
HGNC name guanine nucleotide binding protein-like 3 (nucleolar)-like
HGNC id 25553
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 intestinelarge intestinecolon  
 liver    
 mouthtongue  highly
Lymphoid/Immunespleen    
Reproductivefemale systemuteruscervix highly
 male systemprostate   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a circularly permuted G-motif described by a G5-G4-G1-G2-G3 pattern similar to the HSR1/MMR1 GTP-binding protein subfamily
  • lysine-rich nucleolar localization signal (NoLS) residing within 1-50 amino acid residues, for the transport in the nucleole (necessary and sufficient to target the heterologous proteins to the nucleolus)
  • HOMOLOGY
    interspecies homolog to murine Gnl3l (88.2pc)
    intraspecies paralog to nucleostemin
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • putative GTPase activity
  • is required for growth and plays a role in processing of nucleolar pre-rRNA
  • composed of distinct modules, each of which plays a specific role in molecular interactions for its nucleolar retention and subsequent function(s) within the nucleolus
  • is able to reduce the steroid receptor coactivator (SRC) binding and the SRC-mediated transcriptional coactivation of ESRRG
  • TERF1 protein-stabilizing activity of GNL3L mediates the mitotic increase of TERF1 protein and promotes the metaphase-to-anaphase transition
  • GNL3L and nucleostemin are the only two that are designed to stabilize MDM2 protein under basal or induced condition, respectively, and may act as tumor-promoting genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • TERF1-interacting protein (binds TERF1 in the nucleoplasm and is capable of promoting the homodimerization and telomeric association of TERF1, preventing promyelocytic leukemia body recruitment of telomere-bound TERF1)
  • MDM2 regulator (GNL3L binds MDM2 and displays the same function as nucleostemin in stabilizing MDM2 protein and preventing its ubiquitylation)
  • TERF1 dimerization is actively and oppositely regulated by GNL3 and GNL3L extrachromosomally
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS