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FLASH GENE
Symbol FCHO2 contributors: mct - updated : 26-08-2017
HGNC name FCH domain only 2
HGNC id 25180
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal FCH domain
  • lacks the MP domain but has another lipid-binding domain, the EFC/F-BAR domain , and EFC domain bound to phosphatidylserine and phosphoinositides and deformed the plasma membrane and liposomes into narrow tubes
  • an evolutionarily conserved C-terminal FCHO homology (FOH) domain
  • a mu-homology domain (MHD) that binds directly to DPF sequences in DAB2 that also bind AP2
  • a 90 AA motif, found in both FCHO1, FCHO2 and SGIP proteins, that directly binds TFAP2A
    • HOMOLOGY
    interspecies homolog to murine Fcho2 (94.9pc)
    intraspecies homolog to SGIP1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text localized to clathrin-coated pits at the plasma membrane
    basic FUNCTION
  • FCHO1/FCHO2 sculpt the initial bud site and recruit the clathrin machinery for clathrin-coated vesicle (CCV) formation
  • regulates clathrin-mediated endocytosis through its interactions with membranes and EPS15
  • modulation in the expression level of FCHO1 and FCHO2, which have been reported to initiate clathrin-coated pits (CCPs), affects only the number of nucleations
  • regulates the size of clathrin structures, and its interaction with DAB2 is needed for LDLR endocytosis under conditions of low TFAP2A
  • organizes clathrin-coated structures and interacts with DAB2 for low-density lipoprotein receptor endocytosis
  • FCHO1 and FCHO2 are early-arriving proteins at surface clathrin assemblies and are speculated to act as compulsory coat nucleators, preceding the core clathrin adaptor TFAP2A
  • FCHO1, FCHO2 and SGIP1 stabilize nascent endocytic pits by exposing membrane and cargo binding sites on TFAP2A
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bound to EPS15, an important adaptor protein in clathrin-mediated endocytosis
  • FCHO2 is a major DAB2-interacting protein
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS