basic FUNCTION
| FCHO1/FCHO2 sculpt the initial bud site and recruit the clathrin machinery for clathrin-coated vesicle (CCV) formation |
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regulates clathrin-mediated endocytosis through its interactions with membranes and EPS15 |
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modulation in the expression level of FCHO1 and FCHO2, which have been reported to initiate clathrin-coated pits (CCPs), affects only the number of nucleations |
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regulates the size of clathrin structures, and its interaction with DAB2 is needed for LDLR endocytosis under conditions of low TFAP2A |
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organizes clathrin-coated structures and interacts with DAB2 for low-density lipoprotein receptor endocytosis |
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FCHO1 and FCHO2 are early-arriving proteins at surface clathrin assemblies and are speculated to act as compulsory coat nucleators, preceding the core clathrin adaptor TFAP2A |
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FCHO1, FCHO2 and SGIP1 stabilize nascent endocytic pits by exposing membrane and cargo binding sites on TFAP2A |