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FLASH GENE
Symbol HEPHL1 contributors: mct - updated : 15-05-2024
HGNC name hephaestin-like 1
HGNC id 30477
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to rattus Panx1
Homologene
FAMILY
CATEGORY transport
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • has ferroxidase activity
  • is not essential for the efficient transfer of iron to the fetus but may play a role in placental development
  • HMOX1, SLC40A1 and HEPHL1 are constitutively expressed in terminally differentiated keratinocytes and allow the recycling of iron from heme prior to the cornification of keratinocytes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • ion transport
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Cu2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HJDD
    Susceptibility to risk of advanced colorectal adenoma and cancer
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS