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FLASH GENE
Symbol HEPHL1 contributors: mct - updated : 15-05-2024
HGNC name hephaestin-like 1
HGNC id 30477
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
Reproductivefemale systemplacenta  moderately Homo sapiens
 male systemtestis  moderately
Respiratorylung   highly
Skin/Tegumentskin   predominantly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to rattus Panx1
Homologene
FAMILY
CATEGORY transport
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • has ferroxidase activity
  • is not essential for the efficient transfer of iron to the fetus but may play a role in placental development
  • HMOX1, SLC40A1 and HEPHL1 are constitutively expressed in terminally differentiated keratinocytes and allow the recycling of iron from heme prior to the cornification of keratinocytes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • ion transport
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Cu2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HJDD
    Susceptibility to risk of advanced colorectal adenoma and cancer
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS