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FLASH GENE
Symbol LRRC10 contributors: mct - updated : 04-01-2014
HGNC name leucine rich repeat containing 10
HGNC id 20264
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
7 leucine-rich repeat motifs at the center of the protein
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,cytoskeleton,microfilament
intracellular,nucleus
basic FUNCTION
  • may play important roles in cardiac development and/or cardiac function
  • role in the embryonic as well as adult hearts
  • essential for proper mammalian cardiac function
  • cardiac-specific factor that is crucial for proper cardiac development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LRRC10 is a transcriptional target of NKX2-5 and GATA4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • deletion of Lrrc10 in mice results in dilated cardiomyopathy
  • Lrrc10 -/- mice exhibit prenatal systolic dysfunction and dilated cardiomyopathy in postnatal life