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FLASH GENE
Symbol LRRC10 contributors: mct - updated : 04-01-2014
HGNC name leucine rich repeat containing 10
HGNC id 20264
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiensFetal
 heart     Homo sapiensAdult
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac   Homo sapiensAdult
Muscularstriatumcardiac   Homo sapiensAdult
cells
SystemCellPubmedSpeciesStageRna symbol
Muscularmyocyte Homo sapiensAdult
Muscularmyocyte Homo sapiensFetal
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
7 leucine-rich repeat motifs at the center of the protein
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,cytoskeleton,microfilament
intracellular,nucleus
basic FUNCTION
  • may play important roles in cardiac development and/or cardiac function
  • role in the embryonic as well as adult hearts
  • essential for proper mammalian cardiac function
  • cardiac-specific factor that is crucial for proper cardiac development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LRRC10 is a transcriptional target of NKX2-5 and GATA4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • deletion of Lrrc10 in mice results in dilated cardiomyopathy
  • Lrrc10 -/- mice exhibit prenatal systolic dysfunction and dilated cardiomyopathy in postnatal life