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FLASH GENE
Symbol BOC contributors: mct - updated : 26-03-2012
HGNC name Boc homolog (mouse)
HGNC id 17173
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four Ig repeats
  • three FNIII repeats
  • a single-pass transmembrane domain
  • a 238-residue intracellular region
    • mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Boc
    intraspecies paralog to CDON
    Homologene
    FAMILY
  • immunoglobulin (Ig)/fibronectin type III repeat family
    • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in myogenic differentiation
  • candidate receptor for the action of SHH as an axon guidance ligand
  • axon-guidance molecule playing a fundamental role in pathfinding during the early patterning of the axon scaffold in the embryonic vertebrate brain
  • CDON and BOC encode cell surface Ig/fibronectin superfamily members linked to muscle differentiation
  • CDON and BOC have specific, selective roles in Shh signaling
  • GAS1, CDON, and BOC play overlapping and essential roles during HH-mediated ventral neural patterning of the mammalian neural tube
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming complexes with CDON in a cis fashion via association of both their ectodomains and their intracellular domains
  • APPL1, an interacting partner of AKT1, forms complexes with CDON and BOC in differentiating myoblasts
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding specifically to SHH
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS