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FLASH GENE

Symbol

BOC

contributors: mct - updated : 26-03-2012

HGNC name	Boc homolog (mouse)
HGNC id	17173

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_033254 20 - 4293 NP_150279 - 1114 - 2002 11782431

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive mouth tongue     moderately Lymphoid/Immune thymus       highly Reproductive female system uterus     highly   female system ovary     moderately   male system prostate     moderately Respiratory lung       moderately Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four Ig repeats
	three FNIII repeats
	a single-pass transmembrane domain
	a 238-residue intracellular region

mono polymer

complex

HOMOLOGY

interspecies

ortholog to murine Boc

intraspecies

paralog to CDON

Homologene

FAMILY

immunoglobulin (Ig)/fibronectin type III repeat family

CATEGORY

adhesion , receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	involved in myogenic differentiation
	candidate receptor for the action of SHH as an axon guidance ligand
	axon-guidance molecule playing a fundamental role in pathfinding during the early patterning of the axon scaffold in the embryonic vertebrate brain
	CDON and BOC encode cell surface Ig/fibronectin superfamily members linked to muscle differentiation
	CDON and BOC have specific, selective roles in Shh signaling
	GAS1, CDON, and BOC play overlapping and essential roles during HH-mediated ventral neural patterning of the mammalian neural tube

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	forming complexes with CDON in a cis fashion via association of both their ectodomains and their intracellular domains
	APPL1, an interacting partner of AKT1, forms complexes with CDON and BOC in differentiating myoblasts

INTERACTION

DNA

RNA

small molecule

protein

binding specifically to SHH

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS