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FLASH GENE
Symbol RRN3 contributors: mct - updated : 03-01-2013
HGNC name RRN3 RNA polymerase I transcription factor homolog (yeast)
HGNC id 30346
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a unique HEAT repeat fold and a surface serine patch
    • HOMOLOGY
    interspecies homolog to murine Rrn3
    homolog to drosophila Tif-IA
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in transcription from RNA polymerase I promoter
  • essential, polymerase-associated protein, is inactivated when cells are treated with cycloheximide, resulting in the inhibition of transcription by RNA polymerase I
    • CELLULAR PROCESS nucleotide, transcription, initiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RRN3-regulated Pol I initiation and cell growth
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS