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FLASH GENE

Symbol

RRN3

contributors: mct - updated : 03-01-2013

HGNC name	RRN3 RNA polymerase I transcription factor homolog (yeast)
HGNC id	30346

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p13.11      Physical location : 15.153.880 - 15.188.158

DNA

TYPE	functioning gene
STRUCTURE	34.28 kb     19 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018427 18 - 3762 NP_060897 - 651 - 2002 12015311

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       moderately Lymphoid/Immune spleen       highly Reproductive female system uterus cervix   highly   male system testis     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a unique HEAT repeat fold and a surface serine patch

HOMOLOGY

interspecies	homolog to murine Rrn3
	homolog to drosophila Tif-IA

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,nucleolus

basic FUNCTION	involved in transcription from RNA polymerase I promoter
	essential, polymerase-associated protein, is inactivated when cells are treated with cycloheximide, resulting in the inhibition of transcription by RNA polymerase I

CELLULAR PROCESS

nucleotide, transcription, initiation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

RRN3-regulated Pol I initiation and cell growth

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS