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FLASH GENE
Symbol WDR34 contributors: mct - updated : 13-12-2013
HGNC name WD repeat domain 34
HGNC id 28296
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five WD40 domains
    • HOMOLOGY
    interspecies homolog to rattus Wdr34 (86.1pc)
    homolog to murine Wdr34 (83.1pc)
    homolog to Chlamydomonas reinhardtii Fap133, an intermediate dynein chain that forms part of the retrograde IFT-dynein complex
    Homologene
    FAMILY
  • WD repeat protein family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • concentrates around the centrioles and basal bodies in mammalian cells
    • basic FUNCTION
  • involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation
  • inhibits NR2C2-mediated activation of NF-kappa-B by the IL1-beta and Toll-like receptor pathways (Gao 2009)
  • potential role of WDR34 in retrograde intraflagellar transport 9)
  • is critical for ciliary functions essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-IFT machinery
  • role for WDR34 as a component of the vertebrate dynein-IFT machinery, potentially as a previously unrecognized subunit of the mammalian IFT dynein-2 complex
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NR2C2 (Gao 2009)
  • interacting with MAP3K7IP2, TAB3, TRAF6
  • suppression of GOLGA2 results in mis-localization of WDR34, the intermediate chain of dynein-2
  • acts as a MAP3K7-associated suppressor of the IL1R/TLR3/TLR4-induced NFK&
    • 954;B activation pathway
  • could represent a previously unrecognized link between the cytoplasmic dynein-1 and IFT dynein-2 motors
  • WDR34 is a direct interaction partner of the cytoplasmic dynein-1 light chain DYNLL1
  • TCTEX1D2 associates with WDR34, WDR60, and other subunits of DYNC1 and DYNC2 and colocalizes with WDR60 to microtubule organizing centers during interphase
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SRPS3B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS