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FLASH GENE
Symbol WDR34 contributors: mct - updated : 13-12-2013
HGNC name WD repeat domain 34
HGNC id 28296
DNA
TYPE functioning gene
STRUCTURE 23.19 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1818 - 536 - 2009 1952166
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Reproductivefemale systemuteruscervix highly
 female systemovary   
 female systembreastmammary gland  
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five WD40 domains
  • HOMOLOGY
    interspecies homolog to rattus Wdr34 (86.1pc)
    homolog to murine Wdr34 (83.1pc)
    homolog to Chlamydomonas reinhardtii Fap133, an intermediate dynein chain that forms part of the retrograde IFT-dynein complex
    Homologene
    FAMILY
  • WD repeat protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • concentrates around the centrioles and basal bodies in mammalian cells
  • basic FUNCTION
  • involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation
  • inhibits NR2C2-mediated activation of NF-kappa-B by the IL1-beta and Toll-like receptor pathways (Gao 2009)
  • potential role of WDR34 in retrograde intraflagellar transport 9)
  • is critical for ciliary functions essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-IFT machinery
  • role for WDR34 as a component of the vertebrate dynein-IFT machinery, potentially as a previously unrecognized subunit of the mammalian IFT dynein-2 complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NR2C2 (Gao 2009)
  • interacting with MAP3K7IP2, TAB3, TRAF6
  • suppression of GOLGA2 results in mis-localization of WDR34, the intermediate chain of dynein-2
  • acts as a MAP3K7-associated suppressor of the IL1R/TLR3/TLR4-induced NFK&
  • 954;B activation pathway
  • could represent a previously unrecognized link between the cytoplasmic dynein-1 and IFT dynein-2 motors
  • WDR34 is a direct interaction partner of the cytoplasmic dynein-1 light chain DYNLL1
  • TCTEX1D2 associates with WDR34, WDR60, and other subunits of DYNC1 and DYNC2 and colocalizes with WDR60 to microtubule organizing centers during interphase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SRPS3B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS