Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GDE1 contributors: mct/npt - updated : 15-01-2010
HGNC name glycerophosphodiester phosphodiesterase 1
HGNC id 29644
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative catalytic domain that shares a common motif (amino acids 92-116), with an amino acid sequence resembling the known HKD signature of the phospholipase D family (Corda 2009)
  • the catalytic domains of mammalian phosphoinositide phospholipases C
  • two hydrophobic domains
  • a GDE domain that shares strong homologies with GDE1-related proteins as well as bacterial GDPDs
    • HOMOLOGY
    interspecies homolog to rat Mir16
    Homologene
    FAMILY
  • glycerophosphoryl diester phosphodiesterase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • providing a link between phosphoinositide metabolism and G protein signal transduction
  • catalyzes the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol (Bachmann 2006)
  • mediate glycerophosphoinositol catabolism, leading to different products, potentially reflecting the specific function(s) of glycerophosphoinositol in a given cell system/tissue (Corda 2009)
  • may be involved in the biosynthesis of anandamide (N-arachidonoyl ethanolamine), an endogenous ligand for the brain cannabinoid receptor (Corda 2009)
  • GDE1 plays an important role in linking phosphoinositide metabolism with G protein signal transduction and catalyzes anandamide biosynthesis from glycerophophspho-N-arachidonoylethanolamine precursor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with regulator of G protein signaling proteins
  • interacting protein of the regulator of G protein signaling 16 (RGS16) providing a link between phosphoinositide metabolism and G protein signal transduction (Bachmann 2006)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS