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FLASH GENE

Symbol

GDE1

contributors: mct/npt - updated : 15-01-2010

HGNC name	glycerophosphodiester phosphodiesterase 1
HGNC id	29644

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016641 6 - 2960 NP_057725 37 331 - Bachmann (2006)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       liver         Nervous brain         Reproductive female system ovary         male system prostate       Respiratory lung         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	putative catalytic domain that shares a common motif (amino acids 92-116), with an amino acid sequence resembling the known HKD signature of the phospholipase D family (Corda 2009)
	the catalytic domains of mammalian phosphoinositide phospholipases C
	two hydrophobic domains
	a GDE domain that shares strong homologies with GDE1-related proteins as well as bacterial GDPDs

HOMOLOGY

interspecies

homolog to rat Mir16

Homologene

FAMILY

glycerophosphoryl diester phosphodiesterase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	providing a link between phosphoinositide metabolism and G protein signal transduction
	catalyzes the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol (Bachmann 2006)
	mediate glycerophosphoinositol catabolism, leading to different products, potentially reflecting the specific function(s) of glycerophosphoinositol in a given cell system/tissue (Corda 2009)
	may be involved in the biosynthesis of anandamide (N-arachidonoyl ethanolamine), an endogenous ligand for the brain cannabinoid receptor (Corda 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with regulator of G protein signaling proteins
	interacting protein of the regulator of G protein signaling 16 (RGS16) providing a link between phosphoinositide metabolism and G protein signal transduction (Bachmann 2006)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS