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FLASH GENE
Symbol PPP4R4 contributors: mct/npt - updated : 25-01-2010
HGNC name protein phosphatase 4, regulatory subunit 4
HGNC id 23788
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 15 tandemly repeated HEAT sequences
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in mitotic chromosome condensation
  • displaying weak sequence homology with the A (scaffolding) subunit of the PP2A holoenzyme and specifically associates with PP4C (and not with the related PP2Ac or PP6c phosphatases) (Chen 2008)
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a novel cytosolic complex with PP4C, independent from the complexes containing PP4R1, PP4R2.PP4R3, and alpha4, and the regulatory subunits of PP4C have evolved different modes of interaction with the catalytic subunit (Chen 2008)
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS