Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PPP4R4 contributors: mct/npt - updated : 25-01-2010
HGNC name protein phosphatase 4, regulatory subunit 4
HGNC id 23788
Location 14q32.13      Physical location : 94.640.648 - 94.746.072
Synonym name
  • KIAA1622
  • HEAT-like repeat-containing protein
  • Synonym symbol(s) KIAA1622, PP4R4
    DNA
    TYPE functioning gene
    STRUCTURE 105.42 kb     24 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 923 - 120 - Strausberg, Chen (2008)
  • including alternate exons 4 and 5 missing in variant 1
  • terminating transcription in exon 5
  • having a unique C-terminus that lacks the HEAT-like repeats
  • 24 splicing 3868 99.5 873 - Strausberg, Chen (2008)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  moderately
    Nervousbrainbasal nucleicaudate nucleus moderately
     braindiencephalonamygdala moderately
     brainlimbic systemhippocampus moderately
     spinal cord   lowly
    Reproductivefemale systembreastmammary gland lowly
     female systemovary  lowly
     male systemtestis  lowly
    Visualeye   lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 15 tandemly repeated HEAT sequences
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in mitotic chromosome condensation
  • displaying weak sequence homology with the A (scaffolding) subunit of the PP2A holoenzyme and specifically associates with PP4C (and not with the related PP2Ac or PP6c phosphatases) (Chen 2008)
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a novel cytosolic complex with PP4C, independent from the complexes containing PP4R1, PP4R2.PP4R3, and alpha4, and the regulatory subunits of PP4C have evolved different modes of interaction with the catalytic subunit (Chen 2008)
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS