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FLASH GENE
Symbol NANOS2 contributors: mct/npt - updated : 02-09-2009
HGNC name nanos homolog 2 (Drosophila)
HGNC id 23292
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved zinc-finger domain
    • HOMOLOGY
    Homologene
    FAMILY
  • nanos family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text localizes to the P-bodies, known centers of RNA degradation that are abundantly accumulated in male gonocytes (Suzuki 2010)
    basic FUNCTION
  • required for germ cell development (Suzuki 2007)
  • crucial factor in male germ cell development (Suzuki 2008)
  • involved in the maintenance of stem cells (Suzuki 2009)
  • plays an important role in both the maintenance and sexual development of germ cells (Suzuki 2010)
  • plays a key role during the sexual development of germ cells by suppressing meiosis and promoting male-type differentiation in the embryonic male gonads (Suzuki 2010)
  • plays a role in recruiting the CNOT4 deadenylation complex to trigger the degradation of specific RNAs (Suzuki 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CNOT4 (promotes the localization of CNOT4 and others CNOT proteins to P-bodies)( Suzuki 2010)
  • interacting with STRA8 (Suzuki 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS