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FLASH GENE
Symbol NANOS2 contributors: mct/npt - updated : 02-09-2009
HGNC name nanos homolog 2 (Drosophila)
HGNC id 23292
DNA
TYPE functioning gene
STRUCTURE 1.56 kb     1 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1577 - 138 - Kusz (2009)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text in prenatal germ cells and at later stages in spermatogenesis
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved zinc-finger domain
  • HOMOLOGY
    Homologene
    FAMILY
  • nanos family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text localizes to the P-bodies, known centers of RNA degradation that are abundantly accumulated in male gonocytes (Suzuki 2010)
    basic FUNCTION
  • required for germ cell development (Suzuki 2007)
  • crucial factor in male germ cell development (Suzuki 2008)
  • involved in the maintenance of stem cells (Suzuki 2009)
  • plays an important role in both the maintenance and sexual development of germ cells (Suzuki 2010)
  • plays a key role during the sexual development of germ cells by suppressing meiosis and promoting male-type differentiation in the embryonic male gonads (Suzuki 2010)
  • plays a role in recruiting the CNOT4 deadenylation complex to trigger the degradation of specific RNAs (Suzuki 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CNOT4 (promotes the localization of CNOT4 and others CNOT proteins to P-bodies)( Suzuki 2010)
  • interacting with STRA8 (Suzuki 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS