Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PLPPR4 contributors: mct - updated : 07-09-2020
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six N-terminal
  • membrane-spanning regions with highly conserved phosphatase domains
  • a long hydrophilic domain of approximately 400 AAs, which appears to be located on the cytoplasmic side and may be having a role as a regulatory or signal transduction domain
  • C-terminal putative cytoplasmic domain (AAs 466-766) binds equimolar amounts of CALM1 in a Ca2+-dependent manner, with a relatively high affinity
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • PA-phosphatase related phosphoesterase family
  • PLPPR family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • in the membranes of outgrowing axons
  • localizes at the postsynaptic compartment of excitatory synapses and dendritic shafts of hippocampal neurons, but is not present in presynaptic nerve terminals
    • basic FUNCTION
  • facilitating axonal outgrowth during development and regenerative sprouting
  • may modulate excitatory transmission via lipid phosphate-mediated signaling
  • modulates excitation at the synaptic junction
  • important molecule in the control of hippocampal excitability dependent on presynaptic LPA2 receptor signaling
  • may be involved in postsynaptic functions regulated by intracellular Ca2+-signalling
  • protects neuronal cells from lysophosphatidic acid (LPA) effects
  • protective role in the vascular media under pathophysiological conditions
  • may act by modifying bioactive lipids and their signaling pathways, rather than possessing an ecto-phosphatase activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NEUROD6 directly regulates LPPR4 expression and the NEUROD6 -LPPR4 cascade plays an important role in neurite outgrowth
  • neuronal calmodulin-binding protein
  • new functional cooperation between PLPPR family members and discovered for the first time that PLPPRs likely exert their function through forming complex with its family members
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    may serve as a new therapeutic target for patients with GC peritoneal metastasis
    ANIMAL & CELL MODELS
  • deletion of Prg-1 in mice leads to epileptic seizures and augmentation of excitatory postsynaptic current (EPSC) but not inhibitory postsynaptic current (IPSC)