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FLASH GENE

Symbol

PLPPR4

contributors: mct - updated : 07-09-2020

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	45.30 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014839 7 - 5040 NP_055654 82 763 - 2003 12730698 NM_001166252 6 - 4867 NP_001159724 - 705 - 2003 12730698

EXPRESSION

Type	restricted

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth         Endocrine adrenal gland           neuroendocrine pituitary       Nervous brain       specific   brain limbic system       Homo sapiens   brain forebrain cerebral cortex     Homo sapiens   brain hindbrain cerebellum cerebellar cortex   Homo sapiens Reproductive male system testis     lowly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six N-terminal
	membrane-spanning regions with highly conserved phosphatase domains
	a long hydrophilic domain of approximately 400 AAs, which appears to be located on the cytoplasmic side and may be having a role as a regulatory or signal transduction domain
	C-terminal putative cytoplasmic domain (AAs 466-766) binds equimolar amounts of CALM1 in a Ca2+-dependent manner, with a relatively high affinity

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY	PA-phosphatase related phosphoesterase family
	PLPPR family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
text	in the membranes of outgrowing axons
	localizes at the postsynaptic compartment of excitatory synapses and dendritic shafts of hippocampal neurons, but is not present in presynaptic nerve terminals

basic FUNCTION	facilitating axonal outgrowth during development and regenerative sprouting
	may modulate excitatory transmission via lipid phosphate-mediated signaling
	modulates excitation at the synaptic junction
	important molecule in the control of hippocampal excitability dependent on presynaptic LPA2 receptor signaling
	may be involved in postsynaptic functions regulated by intracellular Ca2+-signalling
	protects neuronal cells from lysophosphatidic acid (LPA) effects
	protective role in the vascular media under pathophysiological conditions
	may act by modifying bioactive lipids and their signaling pathways, rather than possessing an ecto-phosphatase activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	NEUROD6 directly regulates LPPR4 expression and the NEUROD6 -LPPR4 cascade plays an important role in neurite outgrowth
	neuronal calmodulin-binding protein
	new functional cooperation between PLPPR family members and discovered for the first time that PLPPRs likely exert their function through forming complex with its family members

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive stomach may serve as a new therapeutic target for patients with GC peritoneal metastasis

ANIMAL & CELL MODELS

deletion of Prg-1 in mice leads to epileptic seizures and augmentation of excitatory postsynaptic current (EPSC) but not inhibitory postsynaptic current (IPSC)