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FLASH GENE
Symbol PLPPR1 contributors: npt/mct - updated : 07-09-2020
HGNC name lipid phosphate phosphatase-related protein type 1
HGNC id
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
  • plasticity-related gene (PRG) family
  • PLPPR family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • showing dynamic expression regulation during brain development and neuronal excitation
  • involved in mechanisms of neuronal plasticity
  • one of the key enzymes that are involved in the metabolism of phospholipids, such as LPA and S1P, in the nervous system
  • with SLC30A4, MAP1LC3A and CASP3 might play a role in the pathophysiology of recurrent neonatal seizure-induced acute and long-term brain damage
  • LPPR1 is a driver of response to damage
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • new functional cooperation between PLPPR family members and discovered for the first time that PLPPRs likely exert their function through forming complex with its family members
  • PLPPR1 interacts with RasGEF1 (RasGRF1/CDC25), undergoes Ras-induced challenges, whereas deletion of the C-terminal domain of PLPPR1 (PRG3&
    • 916;CT) inhibits RAS
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerative 
    therapeutic target for enhancing neuroregeneration and slowing disease progression
    ANIMAL & CELL MODELS