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FLASH GENE

Symbol

PLPPR1

contributors: npt/mct - updated : 07-09-2020

HGNC name	lipid phosphate phosphatase-related protein type 1
HGNC id

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	296.39 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_207299 8 - 2461 - 325 - 2004 14750979 PRG-3 Ia NM_017753 8 - 2328 - 325 - 2004 14750979 PRG-3 Ib

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain basal nuclei caudate nucleus       brain diencephalon thalamus       brain limbic system hippocampus       brain hindbrain cerebellum

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

HOMOLOGY

Homologene

FAMILY	plasticity-related gene (PRG) family
	PLPPR family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	showing dynamic expression regulation during brain development and neuronal excitation
	involved in mechanisms of neuronal plasticity
	one of the key enzymes that are involved in the metabolism of phospholipids, such as LPA and S1P, in the nervous system
	with SLC30A4, MAP1LC3A and CASP3 might play a role in the pathophysiology of recurrent neonatal seizure-induced acute and long-term brain damage
	LPPR1 is a driver of response to damage

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	new functional cooperation between PLPPR family members and discovered for the first time that PLPPRs likely exert their function through forming complex with its family members
	PLPPR1 interacts with RasGEF1 (RasGRF1/CDC25), undergoes Ras-induced challenges, whereas deletion of the C-terminal domain of PLPPR1 (PRG3&
	916;CT) inhibits RAS

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative   therapeutic target for enhancing neuroregeneration and slowing disease progression

ANIMAL & CELL MODELS