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FLASH GENE

Symbol

MYO18A

contributors: mct - updated : 04-06-2015

HGNC name	myosin XVIIIA
HGNC id	31104

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal domain with a PDZ module mediating protein-protein interaction, and an ATP-insensitive actin-binding site
	two actin binding sites, one is located in the KE-rich region (KEPDZ) at the start of the N-terminal extension and appears to mediate ATP-independent binding to F-actin
	one myosin-like globular head domain
	one Iq domain
	a rodlike tail sequence is highly repetitive, showing cycles of a 28-AA repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils

mono polymer

dimer

HOMOLOGY

Homologene

FAMILY

CATEGORY

motor/contractile , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytoskeleton,microfilament
	intracellular,nucleus

basic FUNCTION	involved in muscle contraction
	may be involved in the maintenance of the stromal cell architectures required for cell to cell contact
	dimeric myosin that might stably cross-link actin filaments by two ATP-insensitive actin-binding sites at the N-terminal domains for higher-order organization of the actin cytoskeleton
	can act as an actin cross-linker with multiple regulatory modulators that targets interacting proteins or complexes to the actin-based cytoskeleton
	can play a role the regulation and organization of the actin cytoskeleton within lamellipodia

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

CDC42BPA and MYO18A linked by the adaptor protein LURAP1 form a functional tripartite complex, which is responsible for the assembly of lamellar actomyosin bundles and of a subnuclear actomyosin network

INTERACTION

DNA

RNA

small molecule

protein	receptor of surfactant protein A
	is a novel binding partner of the PAK2/ARHGEF7/GIT1 complex, suggesting that MYO18A may play an important role in regulating epithelial cell migration via affecting multiple cell machineries
	GOLPH3L antagonizes GOLPH3/MYO18A at the Golgi
	GOLPH3 binds to MYO18A and connects the Golgi apparatus to F-actin to provide a tensile force required for efficient tubule and vesicle formation
	DNA-damage-induced Golgi dispersal requires GOLPH3/MYO18A/F-actin and the DNA damage protein kinase, PRKDC
	with BLZF1 and ARHGEF28, LURAP1 bind MYO18A

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       with PDGFRB in an eosinophilia-associated atypical myeloproliferative neoplasm with a t(5;17)(q33-34;q11.2)(Walz 2009)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS