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FLASH GENE
Symbol MYO18A contributors: mct - updated : 04-06-2014
HGNC name myosin XVIIIA
HGNC id 31104
DNA
TYPE functioning gene
STRUCTURE 106.88 kb     41 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
42 - 7591 233 2054 in mature but not in immature macrophages, and its level increased after the induction of differentiation of M1 cells 2013 2338237
  • MYO18A Ia
  • with an N-terminal PDZ domain
  • 41 - 7546 - 2039 hematopoietic cell-specific 2013 2338237
  • MYO18A Ib
  • lacks a PDZ-domain in the N-terminal region
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   highly
    Respiratoryrespiratory tractlarynx  highly
    Skeletonappendicular skeletonjointsynovia  
    Visualeyeuveachoroid  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningretinal pigment epithelium (RPE)  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain with a PDZ module mediating protein-protein interaction, and an ATP-insensitive actin-binding site
  • two actin binding sites, one is located in the KE-rich region (KEPDZ) at the start of the N-terminal extension and appears to mediate ATP-independent binding to F-actin
  • one myosin-like globular head domain
  • one Iq domain
  • a rodlike tail sequence is highly repetitive, showing cycles of a 28-AA repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils
  • mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microfilament
    intracellular,nucleus
    basic FUNCTION
  • involved in muscle contraction
  • may be involved in the maintenance of the stromal cell architectures required for cell to cell contact
  • dimeric myosin that might stably cross-link actin filaments by two ATP-insensitive actin-binding sites at the N-terminal domains for higher-order organization of the actin cytoskeleton
  • can act as an actin cross-linker with multiple regulatory modulators that targets interacting proteins or complexes to the actin-based cytoskeleton
  • can play a role the regulation and organization of the actin cytoskeleton within lamellipodia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor of surfactant protein A
  • is a novel binding partner of the PAK2/ARHGEF7/GIT1 complex, suggesting that MYO18A may play an important role in regulating epithelial cell migration via affecting multiple cell machineries
  • GOLPH3L antagonizes GOLPH3/MYO18A at the Golgi
  • GOLPH3 binds to MYO18A and connects the Golgi apparatus to F-actin to provide a tensile force required for efficient tubule and vesicle formation
  • DNA-damage-induced Golgi dispersal requires GOLPH3/MYO18A/F-actin and the DNA damage protein kinase, PRKDC
  • with BLZF1 and ARHGEF28, LURAP1 bind MYO18A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with PDGFRB in an eosinophilia-associated atypical myeloproliferative neoplasm with a t(5;17)(q33-34;q11.2)(Walz 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS