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FLASH GENE
Symbol GLTP contributors: mct - updated : 25-03-2010
HGNC name glycolipid transfer protein
HGNC id 24867
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a FFAT-like motif
    • mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Gltp (93.3pc)
    homolog to ratus Gltp (93.8pc)
    Homologene
    FAMILY
  • GLTP family
    • CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzing the transfer of glycosphingolipids and glycoglycerolipids between donor and acceptor membranes
  • potential regulators of cell processes mediated by glycosphingolipids, ranging from differentiation and proliferation to invasive adhesion, neurodegeneration and apoptosis
  • may be involved in the intracelular translocation of glucosylceramides, as a glycolipid sensor (Tuuf 2007)
  • potential role of GLTP in the endoplasmic reticulum association
    • CELLULAR PROCESS cell life, differentiation
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text glycolipid transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with VAPA
    • cell & other
    REGULATION
    Other regulation via mechanistic participation of Sp1/Sp3 transcription factors in a manner influenced by ceramide but not by related sphingolipid metabolites
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS