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FLASH GENE
Symbol GLTP contributors: mct - updated : 25-03-2010
HGNC name glycolipid transfer protein
HGNC id 24867
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2371 - 209 - Li (2004)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas    
Nervousbrainhindbraincerebellum  
Respiratorylung    
 respiratory tractlarynx   
Urinarykidney    
Visualeyeanterior segmentcornea  
cells
SystemCellPubmedSpeciesStageRna symbol
 fibroblast
cell lineage
cell lines detected in various cancer cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a FFAT-like motif
  • mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Gltp (93.3pc)
    homolog to ratus Gltp (93.8pc)
    Homologene
    FAMILY
  • GLTP family
  • CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzing the transfer of glycosphingolipids and glycoglycerolipids between donor and acceptor membranes
  • potential regulators of cell processes mediated by glycosphingolipids, ranging from differentiation and proliferation to invasive adhesion, neurodegeneration and apoptosis
  • may be involved in the intracelular translocation of glucosylceramides, as a glycolipid sensor (Tuuf 2007)
  • potential role of GLTP in the endoplasmic reticulum association
  • CELLULAR PROCESS cell life, differentiation
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text glycolipid transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with VAPA
  • cell & other
    REGULATION
    Other regulation via mechanistic participation of Sp1/Sp3 transcription factors in a manner influenced by ceramide but not by related sphingolipid metabolites
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS