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FLASH GENE
Symbol GPSM2 contributors: mct - updated : 12-07-2015
HGNC name G-protein signaling modulator 2
HGNC id 29501
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four GoLoco domains
  • eight TPR repeats
  • a cysteine-rich region homologous to part of the regulatory domain of protein kinase C
  • conjugated PhosphoP
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies ortholog to drosophila Pins
    homolog to murine Gpsm2 (92.4pc)
    Homologene
    FAMILY
  • GPSM family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • cytoplasmic surface of postsynaptic membranes
  • largely directed to the cell cortex during mitosis (localization dependent on microfilaments)
  • in nucleus and cytoplasm in cells at interphase
  • localized at the spindle in cells at metaphase, and at midzone and midbody in cytokinetic cells
  • restricted localization of GPSM2 and NUMA1 in the lateral belt is instructive for the planar alignment of the mitotic spindle, and required for its planar maintenance
  • basic FUNCTION
  • regulator of G-protein signaling
  • may be linking the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin
  • transducing extracellular signals received by cell surface receptors into integrated cellular responses
  • playing an important role in spindle orientation
  • involved in cell polarity and regulation of spindle organization
  • acting to stabilize the apical complex during neuroblast division
  • important role in cell division of breast cancer cells
  • plays a critical role in cytokinesis
  • critical functions for NUMA1, DCTN1 and GPSM2 in mammalian development
  • NUMA1, DCTN1 and GPSM2 are involved in spindle orientation regulation
  • required for orienting the mitotic spindle during cell division in multiple tissues, suggesting that the sensorineural hearing loss and characteristic brain malformations of CMCS are due to defects in asymmetric cell divisions during development
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUMA1 binding required for spindle movements (oscillations of metaphase spindles)
  • interacting with LLGL2, INSC
  • binding to the alpah subunit of transducin and potentially regulating its function
  • GK domain of DLG1/SAP97 binds to asymmetric cell division regulatory protein GPSM2 in a phosphorylation-dependent manner
  • NUMA1 anaphase localization is independent of GPSM2 and EPB41 interactions, revealing two distinct mechanisms responsible for NUMA1 cortical recruitment at different stages of mitosis
  • endothelial flow mechanotransduction through the junctional complex is mediated by a specific pool of CDH5 that is phosphorylated on Y658 and bound to GPSM2
  • cell & other
    REGULATION
    Other phosphorylated by PBK, which was also upregulated in breast cancer and indispensable for breast cancer cell survival, and the phosphorylation of GPSM2 by PBK was indicated to regulate its function
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB82 , CMCS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in a large proportion of breast cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    PBK/GPSM2 pathway might be a promising molecular target for treatment of breast cancer
    ANIMAL & CELL MODELS
  • cortically polarized in mouse oocytes and is critical for meiotic spindle organization