SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus
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text
| cytoplasmic surface of postsynaptic membranes |
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largely directed to the cell cortex during mitosis (localization dependent on microfilaments) |
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in nucleus and cytoplasm in cells at interphase |
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localized at the spindle in cells at metaphase, and at midzone and midbody in cytokinetic cells |
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restricted localization of GPSM2 and NUMA1 in the lateral belt is instructive for the planar alignment of the mitotic spindle, and required for its planar maintenance |
basic FUNCTION
| regulator of G-protein signaling |
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may be linking the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin |
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transducing extracellular signals received by cell surface receptors into integrated cellular responses |
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playing an important role in spindle orientation |
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involved in cell polarity and regulation of spindle organization |
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acting to stabilize the apical complex during neuroblast division |
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important role in cell division of breast cancer cells |
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plays a critical role in cytokinesis |
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critical functions for NUMA1, DCTN1 and GPSM2 in mammalian development |
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NUMA1, DCTN1 and GPSM2 are involved in spindle orientation regulation |
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required for orienting the mitotic spindle during cell division in multiple tissues, suggesting that the sensorineural hearing loss and characteristic brain malformations of CMCS are due to defects in asymmetric cell divisions during development |