Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PYDC1 contributors: mct/npt - updated : 04-07-2008
HGNC name pyrin domain containing 1
HGNC id 30261
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one CARD domain
  • one DAPIN domain
    • secondary structure six-helix bundle structure with a prominent loop, comprising 13 amino acid residues, between helices two and three
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • promoting caspase-mediated apoptosis predominantly through the activation of caspase 9
  • functions as a modulator of multidomain PYD-containing proteins involved in NF-kappaB and caspase-1 activation
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PYCARD
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS