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FLASH GENE

Symbol

PYDC1

contributors: mct/npt - updated : 04-07-2008

HGNC name	pyrin domain containing 1
HGNC id	30261

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	1.00 kb     2 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 2 - 582 10.1 89 - Natarajan (2006)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine small intestine       Lymphoid/Immune spleen         Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one CARD domain
	one DAPIN domain

secondary structure

six-helix bundle structure with a prominent loop, comprising 13 amino acid residues, between helices two and three

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	promoting caspase-mediated apoptosis predominantly through the activation of caspase 9
	functions as a modulator of multidomain PYD-containing proteins involved in NF-kappaB and caspase-1 activation

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with PYCARD

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS