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FLASH GENE
Symbol FBXO43 contributors: mlc - updated : 20-10-2004
HGNC name F-box protein 43
HGNC id 28521
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a F-box domain
  • a IBR-type zinc finger
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization
  • ANAPC1 inhibitor, implicated as a component of cytostatic factor (CSF) is requires by MOS to induce M phase arrest
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ubiquitin conjugation, third step
    a component part of a SCF (SKP1-cullin-F-box) protein ligase complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may interact with CDC20
  • interaction with the protein phosphatase PPP2R4 (promoted by Rsk phosphorylation )
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS