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FLASH GENE
Symbol FBXO43 contributors: mct - updated : 22-06-2022
HGNC name F-box protein 43
HGNC id 28521
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a F-box domain
  • a D-box and a zinc-binding region (ZBR) implicated in APC/C inhibition
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization
  • ANAPC1 inhibitor, implicated as a component of cytostatic factor (CSF) is requires by MOS to induce M phase arrest
  • FBXO43 proteins accumulate at meiosis I (MI) exit and inhibit APC activity sufficiently to prevent complete degradation of cyclin B, allowing MI exit while preventing interphase before meiosis II (MII) entry
  • inhibits the anaphase-promoting complex/cyclosome (APC/C) and thereby causes metaphase II arrest in unfertilized vertebrate eggs
  • enables centriole amplification during multiciliated cell differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ubiquitin conjugation, third step
    a component part of a SCF (SKP1-cullin-F-box) protein ligase complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may interact with CDC20
  • interaction with the protein phosphatase PPP2R4 (promoted by Rsk phosphorylation )
  • FBXO43 inhibits APC/C-CDC20, and functions as a cytostatic factor that causes long-term M phase arrest of mature oocytes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF64 , OOMD12
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS