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FLASH GENE

Symbol

FBXO43

contributors: mct - updated : 22-06-2022

HGNC name	F-box protein 43
HGNC id	28521

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	OOMD12 oocyte maturation defect 12 SPGF64 spermatogenic failure 64
Location	8q22.2      Physical location : 101.145.587 - 101.158.099
Synonym name	early mitotic inhibitor 2
Synonym symbol(s)	Fbx43, EMI2, ERP1, FBX43, OOMD12, SPGF64

DNA

TYPE	functioning gene
STRUCTURE	17.22 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 6 - 3211 78 708 - 2021 34052850 NM_001029860 5 - 3260 NP_001025031 - 708 - 2021 34052850

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous nerve         Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a F-box domain
	a D-box and a zinc-binding region (ZBR) implicated in APC/C inhibition

HOMOLOGY

Homologene

FAMILY

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization
	ANAPC1 inhibitor, implicated as a component of cytostatic factor (CSF) is requires by MOS to induce M phase arrest
	FBXO43 proteins accumulate at meiosis I (MI) exit and inhibit APC activity sufficiently to prevent complete degradation of cyclin B, allowing MI exit while preventing interphase before meiosis II (MII) entry
	inhibits the anaphase-promoting complex/cyclosome (APC/C) and thereby causes metaphase II arrest in unfertilized vertebrate eggs
	enables centriole amplification during multiciliated cell differentiation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

ubiquitin conjugation, third step

a component

part of a SCF (SKP1-cullin-F-box) protein ligase complex

INTERACTION

DNA

RNA

small molecule

protein	may interact with CDC20
	interaction with the protein phosphatase PPP2R4 (promoted by Rsk phosphorylation )
	FBXO43 inhibits APC/C-CDC20, and functions as a cytostatic factor that causes long-term M phase arrest of mature oocytes

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPGF64 , OOMD12

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS