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FLASH GENE
Symbol FBXO38 contributors: mct - updated : 14-12-2014
HGNC name F-box protein 38
HGNC id 28844
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal F-box domain
  • three nuclear export signals (NES)
  • three C-terminal nuclear localization signals
  • a highly acidic stretch of about 100 amino acids
  • an asp-rich stretch
  • a ser-rich stretch
  • HOMOLOGY
    Homologene
    FAMILY F-box family of proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • preferentially accumulated in the nucleus
  • basic FUNCTION
  • FBXO38 and KLF7 interact functionally to regulate gene expression during cell differentiation and identify the cell cycle regulator CDKN1A) as one of the targeted genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coactivator of the transcription factor Krüppel-like factor 7 (KLF7), which regulates genes required for neuronal axon outgrowth and repair
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DSMACW
    Susceptibility to severe chronic periodontitis
    Variant & Polymorphism SNP
  • rs10043775 associated to severe chronic periodontitis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS