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FLASH GENE
Symbol FBXO38 contributors: mct - updated : 14-12-2014
HGNC name F-box protein 38
HGNC id 28844
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiens
 spinal cord     Homo sapiens
Reproductivemale systemtestis    Homo sapiensAdult
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text developping brain (
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal F-box domain
  • three nuclear export signals (NES)
  • three C-terminal nuclear localization signals
  • a highly acidic stretch of about 100 amino acids
  • an asp-rich stretch
  • a ser-rich stretch
  • HOMOLOGY
    Homologene
    FAMILY F-box family of proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • preferentially accumulated in the nucleus
  • basic FUNCTION
  • FBXO38 and KLF7 interact functionally to regulate gene expression during cell differentiation and identify the cell cycle regulator CDKN1A) as one of the targeted genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coactivator of the transcription factor Krüppel-like factor 7 (KLF7), which regulates genes required for neuronal axon outgrowth and repair
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DSMACW
    Susceptibility to severe chronic periodontitis
    Variant & Polymorphism SNP
  • rs10043775 associated to severe chronic periodontitis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS