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FLASH GENE
Symbol MLF1 contributors: mct/npt - updated : 16-01-2009
HGNC name myeloid leukemia factor 1
HGNC id 7125
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nuclear targeting signal
  • a classic RSXSXP sequence for 14-3-3 binding and is associated with YWHAZ via this phosphorylated motif
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to dog MLF1 (79 pc)
    homolog to chimpanzee MLF1 (98.5 pc)
    homolog to cow MLF1 (81.7 pc)
    homolog to rattus Mlf1 (79 pc)
    homolog to murine MLf1 (81.2 pc)
    Homologene
    FAMILY
  • MLF family
    • CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    text
  • nucleolar when fused with NPM
  • retained in the nucleus by binding to HNRPUL2
  • retained in the cytoplasm by binding to YWHAZ
    • basic FUNCTION
  • involved in normal hemopoietic differentiation as well as in erythroid/myeloid lineage switching
  • interfering with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels
  • suppressing RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest (being a critical regulator of p53)
  • affecting the expression of a number of genes so may function as a transcription factor in the nucleus
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text
  • cell cycle arrest
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with ADAM10 and YWHAZ (influencing its subcellular localization and biological function)
  • interacting with HNRPUL2
  • interacting with MLF1IP
  • interacting with NRBP1/MADM
  • binding to COPS3/CSN3 which is required for suppression of RFWD2 and activation of p53
    • cell & other
    REGULATION
    Other Phosphorylated MLF1 (then binding to YWHAZ and is retained in the cytoplasm)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    translocation t(3;5)(q25.1;q34) with NPM1/NPM in myelodysplastic syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS