basic FUNCTION
| involved in normal hemopoietic differentiation as well as in erythroid/myeloid lineage switching |
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interfering with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels |
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suppressing RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest (being a critical regulator of p53) |
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affecting the expression of a number of genes so may function as a transcription factor in the nucleus |