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FLASH GENE

Symbol

ZNF433

contributors: mct - updated : 13-10-2021

HGNC name	zinc finger protein 433
HGNC id	20811

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	19 C2H2-type zinc fingers
	one KRAB domain

HOMOLOGY

Homologene

FAMILY

Krüppel C2H2-type zinc finger protein family

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	may be involved in transcriptional regulation
	binding partner of CTNNB1 and activated beta-catenin/TCF signaling in prostate cancer
	possible tumor-suppressor gene in clear-cell renal cell carcinoma

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	ion Zn2+

protein

ZNF433 enhanced the binding between CTNNB1 and TCF4

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	prognostic marker in clear-cell renal cell carcinoma
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate ZNF433 was a potential target for the treatment of prostate cancer

ANIMAL & CELL MODELS