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FLASH GENE
Symbol ZNF433 contributors: mct - updated : 13-10-2021
HGNC name zinc finger protein 433
HGNC id 20811
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 19 C2H2-type zinc fingers
  • one KRAB domain
    • HOMOLOGY
    Homologene
    FAMILY
  • Krüppel C2H2-type zinc finger protein family
    • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in transcriptional regulation
  • binding partner of CTNNB1 and activated beta-catenin/TCF signaling in prostate cancer
  • possible tumor-suppressor gene in clear-cell renal cell carcinoma
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    ion Zn2+
    protein
  • ZNF433 enhanced the binding between CTNNB1 and TCF4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • prognostic marker in clear-cell renal cell carcinoma
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    ZNF433 was a potential target for the treatment of prostate cancer
    ANIMAL & CELL MODELS