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FLASH GENE
Symbol USP37 contributors: mct - updated : 14-01-2012
HGNC name ubiquitin specific protease 37
HGNC id 20063
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain of USP37 required for the ZBTB16/RARA interaction and protein regulation
  • three ubiquitin-interacting motif (UIM) repeats
    • HOMOLOGY
    interspecies homolog to murine 4932415L06Rik
    homolog to rattus LOC316522
    Homologene
    FAMILY peptidase family c19
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in ubiquitin-dependent protein catabolism
  • inactive in mitosis because it was no longer phosphorylated by CDK2
  • gatekeeper of APC/C-mediated ubiquitination of cyclin A
    • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds CDH1 and removes degradative polyubiquitin from cyclin A
  • USP37 interacted with ZBTB16/RARA through the PLZF moiety and sustained ZBTB16/RARA steady state levels
    • cell & other
    REGULATION
    induced by E2F transcription factors in G1, peaked at G1/S, and was degraded in late mitosis
    Phosphorylated by CDK2 that stimulated its full activity
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS