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FLASH GENE

Symbol

USP37

contributors: mct - updated : 14-01-2012

HGNC name	ubiquitin specific protease 37
HGNC id	20063

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	118.11 kb     26 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020935 26 - 8032 - 979 - 2004 14715245

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Nervous brain       highly Reproductive female system ovary         male system testis       Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal domain of USP37 required for the ZBTB16/RARA interaction and protein regulation
	three ubiquitin-interacting motif (UIM) repeats

HOMOLOGY

interspecies	homolog to murine 4932415L06Rik
	homolog to rattus LOC316522

Homologene

FAMILY

peptidase family c19

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in ubiquitin-dependent protein catabolism
	inactive in mitosis because it was no longer phosphorylated by CDK2
	gatekeeper of APC/C-mediated ubiquitination of cyclin A

CELLULAR PROCESS	protein, degradation
	protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binds CDH1 and removes degradative polyubiquitin from cyclin A
	USP37 interacted with ZBTB16/RARA through the PLZF moiety and sustained ZBTB16/RARA steady state levels

cell & other

REGULATION

induced by

E2F transcription factors in G1, peaked at G1/S, and was degraded in late mitosis

Phosphorylated by

CDK2 that stimulated its full activity

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS