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FLASH GENE
Symbol PRDX6 contributors: mct - updated : 24-01-2017
HGNC name peroxiredoxin 6
HGNC id 16753
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a potential catalytic triad (S32, H26, D140) from the crystal structure, that can plays an essential role for interactions of Prdx6 with phospholipid substrate to optimize the protein-substrate complex for hydrolysis
    • HOMOLOGY
    interspecies homolog to murine Prdx6
    homolog to Drosophila Prx6005
    homolog to C.elegans Y38C1AA.1
    Homologene
    FAMILY
  • thiol-specific antioxidant protein family
  • Rehydrin subfamily
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • localization in acidic organelles and consequent PLA2 activity depend on a novel 10-AAs peptide located at positions 31-40 of the protein
  • localized mainly in the nucleus of neural cells
    • basic FUNCTION
  • "moonlighting" protein with both GSH peroxidase and phospholipase A2 (PLA2)) activities
  • involved in redox regulation of the cell
  • reducing H(2)O(2) and short chain organic, fatty acid and phospholipid hydroperoxides
  • playing a role in the regulation of phospholipid turnover as well as in protection against oxidative injury
  • regulating, with arachidonic acid, striated muscle growth by modulating multiple growth-regulatory pathways
  • bifunctional enzyme with two distinct active sites
  • required for blood vessel integrity in wounded skin
  • important antioxidant enzyme in human brain defenses
  • attenuates oxidative stress- and TGFbeta-induced abnormalities of trabecular meshwork cells
  • binds to reduced phospholipid at acidic pH but at cytosolic pH binds only phospholipid that is oxidized compatible with a role in the repair of peroxidized cell membranes
  • in uterus PRDX6 also plays antioxidant roles in human implantation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • phospholipd and lipid catabolism
  • FKBP4–PRDX6 signaling protects pregnancy from overt oxidative stress
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct interaction between SFTPA1, which provides a mechanism for regulation of the PLA(2) activity of PRDX6 by SFTPA1
  • physical interaction between FKBP4 and PRDX6 suggests that FKBP4 stabilizes PRDX6 protein and attenuates its degradation as a function of its chaperone activity
    • cell & other
    REGULATION
    inhibited by irreversibly inactivated by overoxidation of Cys-46 (to CYS-SO3H) upon oxidative stress
    Other regulated by FKBP4
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Alzheimer disease, there were marked increases in the number and staining intensity of PRDX6 positive astrocytes in both gray and white matter in the midfrontal cortex, cingulate, hippocampus and amygdala
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS