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FLASH GENE
Symbol PRDX6 contributors: mct - updated : 24-01-2017
HGNC name peroxiredoxin 6
HGNC id 16753
DNA
TYPE functioning gene
STRUCTURE 11.46 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
HCP3 1q23.3 cytochrome c, somatic pseudogene XTP2 1q23.3 HBxAg transactivated protein 2 MYOC 1q24.3-q25.2 myocilin, trabecular meshwork inducible glucocorticoid response LOC391134 1 similar to Chain  , Profilin LOC391135 1 similar to ribosomal protein L4; 60S ribosomal protein L4; homologue of Xenopus ribosomal protein L1 VAMP4 1q24-q25 vesicle-associated membrane protein 4 LOC391136 1 similar to RNA binding motif protein 3 CGI-01 1q24-q25.3 CGI-01 protein LOC391137 1 similar to dJ612B18.1 (similar to 40S ribosomal protein) LOC127099 1q24.1 similar to 60S ACIDIC RIBOSOMAL PROTEIN P1 KIAA0820 1q24 similar to 60S ACIDIC RIBOSOMAL PROTEIN P1 LOC92346 1q24.1 LOC92346 PIGC 1q23-q25 phosphatidylinositol glycan, class C C1orf9 1q24 chromosome 1 open reading frame 9 TNFSF6 1q23.3 tumor necrosis factor (ligand) superfamily, member 6 LOC391138 1 similar to Multisynthetase complex auxiliary component p43 TNFSF18 1q23 tumor necrosis factor (ligand) superfamily, member 18 LOC391139 1 similar to Aspartate aminotransferase, mitochondrial precursor (Transaminase A) (Glutamate oxaloacetate transaminase-2) TNFSF4 1q25 tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa) LOC343153 1q24.2 similar to ribosomal protein L26 PRDX6 1q24.1 peroxiredoxin 6 MGC43026 1q24.2 hypothetical protein MGC43026 FLJ45235 1q24.2 FLJ45235 protein AB026190 1q24.1-q24.3 Kelch motif containing protein dJ383J4.3 1q24.1 hypothetical gene supported by BC007071 FLJ10514 1q24.2 hypothetical protein FLJ10514 RNU47 1q23.3 RNA, U47 small nuclear MGC2629 1q24.2 hypothetical protein MGC2629 SERPINC1 1q24-q25.1 serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 KIAA2025 1q24.2 KIAA2025 protein GPR52 1q24 G protein-coupled receptor 52 HHL 1q24 expressed in hematopoietic cells, heart, liver SIP 1q24-q25 expressed in hematopoietic cells, heart, liver MRPS14 1q23-1q25 mitochondrial ribosomal protein S14 LOC388715 1 LOC388715 TNN 1q23-q24 tenascin N KIAA0040 1q24-25 tenascin N TNR 1q24 tenascin R (restrictin, janusin)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1715 - 224 - 2009 19572226
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Nervousbrain   moderately Homo sapiens
Reproductivefemale systemuteruscervix highly
Visualeyeretina  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Epithelialabsorptive excretoryalveolar epithelium highly
Epithelialbarrier liningendometrium   Homo sapiens
Nervouscentral    Homo sapiensFetal
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythrocyte
Nervousastrocyte Homo sapiens
Nervousglia Homo sapiens
Nervousneuron Homo sapiens
VisualMuller cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a potential catalytic triad (S32, H26, D140) from the crystal structure, that can plays an essential role for interactions of Prdx6 with phospholipid substrate to optimize the protein-substrate complex for hydrolysis
  • HOMOLOGY
    interspecies homolog to murine Prdx6
    homolog to Drosophila Prx6005
    homolog to C.elegans Y38C1AA.1
    Homologene
    FAMILY
  • thiol-specific antioxidant protein family
  • Rehydrin subfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • localization in acidic organelles and consequent PLA2 activity depend on a novel 10-AAs peptide located at positions 31-40 of the protein
  • localized mainly in the nucleus of neural cells
  • basic FUNCTION
  • "moonlighting" protein with both GSH peroxidase and phospholipase A2 (PLA2)) activities
  • involved in redox regulation of the cell
  • reducing H(2)O(2) and short chain organic, fatty acid and phospholipid hydroperoxides
  • playing a role in the regulation of phospholipid turnover as well as in protection against oxidative injury
  • regulating, with arachidonic acid, striated muscle growth by modulating multiple growth-regulatory pathways
  • bifunctional enzyme with two distinct active sites
  • required for blood vessel integrity in wounded skin
  • important antioxidant enzyme in human brain defenses
  • attenuates oxidative stress- and TGFbeta-induced abnormalities of trabecular meshwork cells
  • binds to reduced phospholipid at acidic pH but at cytosolic pH binds only phospholipid that is oxidized compatible with a role in the repair of peroxidized cell membranes
  • in uterus PRDX6 also plays antioxidant roles in human implantation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • phospholipd and lipid catabolism
  • FKBP4PRDX6 signaling protects pregnancy from overt oxidative stress
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct interaction between SFTPA1, which provides a mechanism for regulation of the PLA(2) activity of PRDX6 by SFTPA1
  • physical interaction between FKBP4 and PRDX6 suggests that FKBP4 stabilizes PRDX6 protein and attenuates its degradation as a function of its chaperone activity
  • cell & other
    REGULATION
    inhibited by irreversibly inactivated by overoxidation of Cys-46 (to CYS-SO3H) upon oxidative stress
    Other regulated by FKBP4
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Alzheimer disease, there were marked increases in the number and staining intensity of PRDX6 positive astrocytes in both gray and white matter in the midfrontal cortex, cingulate, hippocampus and amygdala
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS