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FLASH GENE
Symbol PPM1L contributors: - updated : 17-05-2006
HGNC name protein phosphatase 1 (formerly 2C)-like
HGNC id 16381
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a PP2C-like domain
HOMOLOGY
interspecies ortholog to murine Ppm1l
ortholog to rattus Ppm1l
Homologene
FAMILY PP2C family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • ser/thr protein phosphatase activity
  • may have a role in the regulation of IL1-TAK1 signaling pathway via its interaction with TAK1 and its dephosphorylation, maintaining it in an inactive state
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Mg2+ or Mn2+ dependent phosphatase activity
    protein
  • associates stably with TAK1
    • cell & other
    REGULATION
    Other dissociates from TAK1 by IL1 treatment
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS