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FLASH GENE
Symbol PPM1L contributors: - updated : 17-05-2006
HGNC name protein phosphatase 1 (formerly 2C)-like
HGNC id 16381
DNA
TYPE functioning gene
STRUCTURE 228.00 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveliver   highly
Nervousbrain   highly
Reproductivemale systemtestis   
Respiratorylung   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a PP2C-like domain
HOMOLOGY
interspecies ortholog to murine Ppm1l
ortholog to rattus Ppm1l
Homologene
FAMILY PP2C family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • ser/thr protein phosphatase activity
  • may have a role in the regulation of IL1-TAK1 signaling pathway via its interaction with TAK1 and its dephosphorylation, maintaining it in an inactive state
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Mg2+ or Mn2+ dependent phosphatase activity
    protein
  • associates stably with TAK1
    • cell & other
    REGULATION
    Other dissociates from TAK1 by IL1 treatment
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS