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FLASH GENE
Symbol SUCLG2 contributors: mct/npt - updated : 03-11-2015
HGNC name succinate-CoA ligase, GDP-forming, beta subunit
HGNC id 11450
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • succinate/malate CoA ligase beta subunit family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    text
  • exist only in cells forming the vasculature or its contents in the human brain
    • basic FUNCTION
  • catalyze the reverse reaction in the citric acid cycle in which the ADP-forming enzyme augments ATP production, whereas the GDP-forming enzyme supports GTP-dependent anabolic processes (Lambeth 204)
  • SUCLG2, to a higher degree than SUCLA2, is crucial for mtDNA maintenance and mitochondrial NME1 is involved
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS