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FLASH GENE

Symbol

SUCLG2

contributors: mct/npt - updated : 03-11-2015

HGNC name	succinate-CoA ligase, GDP-forming, beta subunit
HGNC id	11450

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p14.1      Physical location : 67.410.884 - 67.705.038
Synonym name	succinyl-CoA ligase, GDP-forming, beta chain, mitochondrial precursor
	succinyl-CoA synthetase, beta-G chain
	GTP-specific succinyl-CoA synthetase beta subunit
Synonym symbol(s)	G-BETA, SCB2, SCS-betaG
EC.number	6.2.1.4

DNA

TYPE	functioning gene
STRUCTURE	294.15 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003848 11 - 2369 NP_003839 - 432 - 2004 15234968 NM_001177599 11 - 1520 NP_001171070 - 440 - 2004 15234968

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel         Homo sapiens Nervous brain hindbrain medulla oblongata     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	stem cells

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

succinate/malate CoA ligase beta subunit family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
text	exist only in cells forming the vasculature or its contents in the human brain

basic FUNCTION	catalyze the reverse reaction in the citric acid cycle in which the ADP-forming enzyme augments ATP production, whereas the GDP-forming enzyme supports GTP-dependent anabolic processes (Lambeth 204)
	SUCLG2, to a higher degree than SUCLA2, is crucial for mtDNA maintenance and mitochondrial NME1 is involved

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS