Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol WDR26 contributors: mct/npt/pgu - updated : 24-08-2017
HGNC name WD repeat domain 26
HGNC id 21208
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved WD40 repeat domain that is present in a large family of proteins confined primarily to eukaryotic organisms
    • HOMOLOGY
    interspecies homolog to murine Wdr26
    Homologene
    FAMILY
  • WD40 repeat protein family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • can be located at mitochondria
    • basic FUNCTION
  • WD-40 repeat proteins playing important roles in a variety of cellular functions, such as cell growth, proliferation, apoptosis and intracellular signal transduction
  • up-regulated by oxidative stress and playing a key role in H2O2-induced neural cell death, which may be mediated by the down-regulation of AP-1 transcriptional activity
  • may act as a negative regulator in MAPK signaling pathway and play an important role in cell signal transduction
  • is required for leukocyte chemotaxis
  • plays a critical role in regulating Gbeta-gamma-dependent leukocyte migration
  • its expression can inhibit apoptosis induced by H(2)O(2)and WDR26 inhibit cytochrome c release from mitochondria
  • required for PLCB2 translocation from the cytosol to the membrane in polarized leukocytes, and the translocation of PLCB2 was sufficient to cause partial activation of PLCB2
  • functions as a scaffolding protein to promote PLCB2 membrane translocation and interaction with Gbeta-gamma, thereby enhancing PLCB2 activation in leukocytes
  • plays a negative role in CTNNB1 degradation in the Wnt signaling pathway
  • is a mediator of response to hypoxia, and WDR26 plays an important role in hypoxia-mediated autophagy and mitophagy.
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a novel GNG2/GNB1-binding protein that is required for the efficacy of GNG2/GNB1 signaling and leukocyte migration
  • WDR26 also controlled GNB2L1, a negative regulator, in binding GNG2/GNB1 and inhibiting leukocyte migration
  • not only directly bound GNG2/GNB1 but also PLCB2 (the binding sites of WDR26 and PLCB2 on GNG2/GNB1 were overlapping but not identical)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SKDEAS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the cell inhibits the transcriptional activities of ETS proteins, ELK-1 and c-fos serum response element (SRE), mediated by MAP3K1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularatheromacardiac
    may serve as a potential target for the treatment of myocardial ischemia
    cancerreproductivebreast
    potential therapeutic target for breast cancer
    ANIMAL & CELL MODELS