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FLASH GENE
Symbol WDR26 contributors: mct/npt/pgu - updated : 24-08-2017
HGNC name WD repeat domain 26
HGNC id 21208
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved WD40 repeat domain that is present in a large family of proteins confined primarily to eukaryotic organisms
  • HOMOLOGY
    interspecies homolog to murine Wdr26
    Homologene
    FAMILY
  • WD40 repeat protein family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • can be located at mitochondria
  • basic FUNCTION
  • WD-40 repeat proteins playing important roles in a variety of cellular functions, such as cell growth, proliferation, apoptosis and intracellular signal transduction
  • up-regulated by oxidative stress and playing a key role in H2O2-induced neural cell death, which may be mediated by the down-regulation of AP-1 transcriptional activity
  • may act as a negative regulator in MAPK signaling pathway and play an important role in cell signal transduction
  • is required for leukocyte chemotaxis
  • plays a critical role in regulating Gbeta-gamma-dependent leukocyte migration
  • its expression can inhibit apoptosis induced by H(2)O(2)and WDR26 inhibit cytochrome c release from mitochondria
  • required for PLCB2 translocation from the cytosol to the membrane in polarized leukocytes, and the translocation of PLCB2 was sufficient to cause partial activation of PLCB2
  • functions as a scaffolding protein to promote PLCB2 membrane translocation and interaction with Gbeta-gamma, thereby enhancing PLCB2 activation in leukocytes
  • plays a negative role in CTNNB1 degradation in the Wnt signaling pathway
  • is a mediator of response to hypoxia, and WDR26 plays an important role in hypoxia-mediated autophagy and mitophagy.
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a novel GNG2/GNB1-binding protein that is required for the efficacy of GNG2/GNB1 signaling and leukocyte migration
  • WDR26 also controlled GNB2L1, a negative regulator, in binding GNG2/GNB1 and inhibiting leukocyte migration
  • not only directly bound GNG2/GNB1 but also PLCB2 (the binding sites of WDR26 and PLCB2 on GNG2/GNB1 were overlapping but not identical)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SKDEAS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the cell inhibits the transcriptional activities of ETS proteins, ELK-1 and c-fos serum response element (SRE), mediated by MAP3K1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularatheromacardiac
    may serve as a potential target for the treatment of myocardial ischemia
    cancerreproductivebreast
    potential therapeutic target for breast cancer
    ANIMAL & CELL MODELS