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FLASH GENE
Symbol PRICKLE2 contributors: mct/npt - updated : 17-02-2014
HGNC name prickle homolog 2 (Drosophila)
HGNC id 20340
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three LIM domains
  • one PET domain
  • Cterminal Prickle homologous domain (PKH)
    • HOMOLOGY
    interspecies homolog to xenopus Prickle
    intraspecies homolog to PRICKLE1
    Homologene
    FAMILY
  • LIM-only protein 6 family
  • prickle/espinas/testin family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text nuclear membrane
    basic FUNCTION
  • involved in tissue polarity or planar polarity
  • function in the noncanonical WNT signaling pathway, which regulates intracellular calcium release and planar cell polarity (PCP)
  • PRICKLE1, PRICKLE2 possibly regulate positive neurite formation during brain development
  • its farnesylation is essential for its nuclear localization and nuclear localization of PRICKLE2 is critical for its function
  • PRICKLE2 and IGSF9B coordinately regulate the cytoarchitecture of the axon initial segment
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRICKLE1 and PRICKLE2 promote neurite-like process formation of neuroblastoma cells via the DVL1 dependent mechanism
  • is a novel postsynaptic density (PSD) protein that interacts with DLG4 and NMDA receptors through complex formations in the brain
  • PRICKLE2 regulates ANK3 distribution by controlling the proper localization of IGSF9B
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EGI2
    Susceptibility to Autism spectrum disorders (ASDs)
    Variant & Polymorphism other
  • variants causing a critical loss of PRICKLE2 function, are associated with ASD
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice with disruption in Prickle2 display behavioral abnormalities including altered social interaction, learning abnormalities and behavioral inflexibility